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The title of this paper is: Final results from the vedolizumab extended access program multinational study demonstrate long-term treatment persistence and safety
The first author is: Silvio Danese
The paper was published in: 'Therapeutic Advances in Gastroenterology' in January 2026.

For those in a hurry, here is a brief overview of the paper:This phase IIIb/IV prospective multinational study (XAP) evaluated long-term vedolizumab treatment persistence and safety in 331 patients (142 UC, 189 CD) who rolled over from the GEMINI LTS or VERSIFY trials. Most patients (89%) entered on every-8-week (Q8W) dosing, with over 80% in clinical remission at baseline. Treatment persistence on Q8W without relapse for at least 6 months was 98% for UC and 95% for CD. Only 9% required dose escalation back to Q4W. Mean treatment duration in the XAP was approximately 3.5 years. Serious adverse events occurred in 15% of patients, with only 0.6% considered treatment-related. Serious infections were rare (1.8%) and none were attributed to vedolizumab. These results support the durable effectiveness and long-term safety of vedolizumab in IBD patients..

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Below is an example for gatroenterology and some of the categories available to select from. Your article feed can be more general or you can get as specific as you like. You choose.

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Biomarkers in IBD

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